Em, Cee-Lo, Lady Gaga, Miranda Lambert and Katy Perry will perform during the awards ceremony, which will be broadcast live from Los Angeles next month.
Of all the performers, Eminem snagged the most nominations for a single artist, earning 10 nominations in categories like Best Rap Song, Song of the Year and Album of the year, for his best-selling album, Recovery.
Cee Lo Green is up for four awards as well, for his hit single "F**k You."
"This year's nominations are a true reflection of an exceptional and talented community of music makers that embody some of the highest levels of excellence and artistry in their respective fields," said Neil Portnow, President/CEO of The Recording Academy.
The 53rd Annual Grammy Awards take place on February 13th at The Staples Center in Los Angeles, from 8PM-11 EST.