6. Nick Fury —
Traditionally, S.H.I.E.L.D. head honcho Nick Fury has been portrayed as an Italian-American. David Hasselhoff even played him in a campy B-movie film. It wasn't until the Ultimate Marvel universe was created that General Fury received an upgrade. His look and personality was tailored after actor Samuel L. Jackson and has been personally played by the high grossing thespian in most of Marvel's big blockbuster films.
Making a stand-alone film a necessity for the S.H.I.E.L.D. agent with the eye-patch.