The reality show curse hits again, this time taking a stab at America's most famous family, the Kardashians. While most of us have been focused on Khloe Kardashian and  Lamar Odom's drug problem, mama Jenner threw in the marriage towel. After 22 years of marital bliss, Kris and Bruce Jenner have officially split up. "Even though we are separated, we will always remain best friends and, as always, our family will remain our number one priority," the couple said in a joint statement to E!.

They aren't the first couple to go down splitsville after filming their relationship's ups and downs for the world to watch. They are the most surprising but definitely not the first. Take a look at other celebrities that broke up after starring in a reality show together.

Photo Credit: People

Lisa Wu-Hartwell and Ed Hartwell
Show: Real Housewives of Atlanta

Photo Credit: Freddy Yo

Jessica Simpson and Nick Lachey
Show: Newlyweds

Photo Credit: She Knows

Jennifer and Eric Williams
Show: Basketball Wives

Bethenny Frankel & Jason Hoppy
Show: Bethenny Getting Married & Bethenny Ever After

Photo Credit:Hooked on Houses

Hulk and Linda Hogan 
Show: Hogan Knows Best

Photo Credit: Asian Town

Dawn and Que
Show: Making The Band

Photo Credit: Necole Bitchie

Whitney Houston and Bobby Brown
Show: Being Bobby Brown


Evelyn Lozado and Ocho Cinco
Show: Basketball Wives

Travis Barker & Shanna Moakler
Show: Meet The Barkers

Photo Credit: Snarker ATI

Kris Humphries and Kim Kardashian
Show: Keeping up with The Kardashians

Leah Messer & Corey Simms
Show: MTV's Teen Mom

Photo Credit: Starcasm 

Carmen Electra & Dave Navarro
Show: 'Til Death Do Us Part

Photo Credit: Zimbio

Kate & Jon Gosselin
Show: Jon & Kate Plus 8

Photo Credit: Online Athens