"Letitia kindly asks that you keep her in your prayers," said a representative for the actress.
Dorothy Steel, the 95-year-old actress who played a tribe leader in the first film, has also passed away.
The British-Ghanaian actress has joined the cast of the highly anticipated sequel, which recently began filming in Atlanta.
"We're going to do it in a way that would make Chad proud," said Marvel Studios Chief Kevin Feige.
The groundbreaking director is taking his talents to a new television series based in the Kingdom of Wakanda.
Princess Shuri, played by Letitia Wright, might take on a larger role in the Marvel film.
“I haven’t grieved a loss this acute before.”