The longtime couple announced the news ahead of Diab's return to red carpet hosting.
The team's owner previously expressed support for the quarterback.
The theme for the evening is "Truth Is Power."
"Come in, let me compete. If I'm not good enough, get rid of me. But let me come in and show you," said Kaepernick.
Em has publicly shown his support of Kaepernick and his protest on multiple occasions, including a 2017 BET Hip Hop Awards performance.
"I see you bro, and I know God is with you," Cole wrote. "I pray the day soon comes when you get to play the game you love at the highest level again."
The untitled project will include exclusive interviews and never-before-seen archival footage from Kaepernick's life.
"Before they put you on the field, teams poke, prod, and examine you searching for any defect that might affect your performance," said Kaepernick of NFL organizations.
"It was vitally important to me that this wasn't another autobiographical series about a famous person as a child," said DuVernay.