Weezy will also be a special guest performer.
GloRilla, Kendrick Lamar, and Beyoncé are among this year's class of historic nominees.
Streaming live after 'Thursday Night Football', the series is hosted by 2 Chainz.
Weezy also held Jay-Z to the highest regard as "Hip-Hop's G.O.A.T." during the discussion.
He also recalled the "saddest" thing he ever saw while visiting Wayne behind bars.
Weezy recently showed up to support Missy at the unveiling of her wax figure at Madame Tussauds.
The event occurred as the rapper visited his hometown for the Lil Weezyana Fest.
The nostalgic celebrity homes show has returned, kicking off with Dwight Howard, Nicole Scherzinger and more.