Coogler and Bank of America have issued statements regarding the situation.
The actress had a five-month recovery period after she suffered a critical shoulder fracture while filming an action scene as Shuri.
"Letitia kindly asks that you keep her in your prayers," said a representative for the actress.
Dorothy Steel, the 95-year-old actress who played a tribe leader in the first film, has also passed away.
The British-Ghanaian actress has joined the cast of the highly anticipated sequel, which recently began filming in Atlanta.
While no specific details have been revealed, Shaka King will direct the project as well co-produce alongside Coogler, Lil Rel Howery, and Charles King.
The actress's role as general of Wakanda's Dora Milaje will continue in the Marvel Cinematic Universe.
The groundbreaking director is taking his talents to a new television series based in the Kingdom of Wakanda.