H.E.R. and Wizkid also took home prestigious awards.
The annual ceremony brought sweet soul to New York City's Apollo Theater on the music-dance program's 50th anniversary.
Doja Cat and H.E.R. are the most nominated women and Jay-Z breaks a record set by Quincy Jones.
The theme, Made In Africa, was set with the purpose of "encouraging the further advancement and awareness of Africa's homegrown talent in music, art, fashion, and food."
Wearing a silky tangerine-toned two-piece set and matching printed headwrap, she began with "Found" from her latest released EP 'If Orange Was A Place.'
The man that is taking Afrobeats around the world, comes to New York and sets the stage ablaze.
Hosted by Doja Cat, tonight's show will air live at 8 p.m. ET/PT from the Barclay's Center in Brooklyn, N.Y. and feature performances by Lil Nas X, Chlöe, and Polo G.
This is a milestone for the West African genre of Afrobeats.