The new drama series will also be executive produced by the actress, author, and comedian.
She was drinking champagne in the clip that sparked the gossip.
The series follows a group of single parents who have been nominated by their college-age kids for a second chance at love.
"Can't believe this is the last #InsecureHBO trailer I'll ever share," the media mogul wrote on Twitter.
Like the series, the one-minute trailer takes viewers through the highs and lows of the group of friends and lovers.
"My girls came to help me, but they all coincidentally had on the same dress! They were sooooo embarrassed," she joked on Instagram.
"Best believe lots of shenanigans ensued," Ojri wrote on Instagram. The raunchy comedy also stars John Cena and Meredith Hagner.